CATH Domain 1kfuL02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.70	Cathepsin B; Chain A
	3.90.70.10	Cysteine proteinases

Domain Context

CATH Clusters

Superfamily	Cysteine proteinases
Functional Family	Calpain-1 catalytic subunit

Enzyme Information

3.4.22.53

Calpain-2.

based on mapping to UniProt P17655

Broad endopeptidase specificity.

-!- Cytosolic in animal cells. -!- The active enzyme molecule is a heterodimer in which the large subunit contains the peptidase unit, and the small subunit is also a component of EC 3.4.22.52. -!- Belongs to peptidase family C2. -!- Formerly EC 3.4.22.17 and EC 3.4.24.5.

UniProtKB Entries (1)

P17655

CAN2_HUMAN

Homo sapiens

Calpain-2 catalytic subunit

PDB Structure

PDB	1KFU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium. Strobl, S., Fernandez-Catalan, C., Braun, M., Huber, R., Masumoto, H., Nakagawa, K., Irie, A., Sorimachi, H., Bourenkow, G., Bartunik, H., Suzuki, K., Bode, W. Proc.Natl.Acad.Sci.USA

Network disruptions