CATH Classification

Domain Context

CATH Clusters

Superfamily Beta Polymerase, domain 2
Functional Family DNA nucleotidylexotransferase

Enzyme Information

3.1.11.-
Exodeoxyribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt P09838
2.7.7.31
DNA nucleotidylexotransferase.
based on mapping to UniProt P09838
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes template-independent extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Nucleoside may be ribo- or deoxyribo-.

UniProtKB Entries (1)

P09838
TDT_MOUSE
Mus musculus
DNA nucleotidylexotransferase

PDB Structure

PDB 1KEJ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of a template-independent DNA polymerase: murine terminal deoxynucleotidyltransferase.
Delarue, M., Boule, J.B., Lescar, J., Expert-Bezancon, N., Jourdan, N., Sukumar, N., Rougeon, F., Papanicolaou, C.
EMBO J.