CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome c-like domain
Functional Family

Enzyme Information

1.1.9.1
Alcohol dehydrogenase (azurin).
based on mapping to UniProt Q46444
A primary alcohol + azurin = an aldehyde + reduced azurin.
-!- Occurs in Comamonas and Pseudomonas. -!- Does not require an amine activator. -!- Oxidizes a wide range of primary and secondary alcohols, and also aldehydes and large substrates such as sterols; methanol is not a substrate. -!- Usually assayed with phenazine methosulfate or ferricyanide. -!- Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed 'propeller' structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ. -!- Formerly EC 1.1.98.1.

UniProtKB Entries (1)

Q46444
QHED_COMTE
Comamonas testosteroni
Quinohemoprotein alcohol dehydrogenase

PDB Structure

PDB 1KB0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of quinohemoprotein alcohol dehydrogenase from Comamonas testosteroni: structural basis for substrate oxidation and electron transfer.
Oubrie, A., Rozeboom, H.J., Kalk, K.H., Huizinga, E.G., Dijkstra, B.W.
J.Biol.Chem.