CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.5.1300
Functional Family Histidine biosynthesis trifunctional protein

Enzyme Information

1.1.1.23
Histidinol dehydrogenase.
based on mapping to UniProt P06988
L-histidinol + H(2)O + 2 NAD(+) = L-histidine + 2 NADH.
-!- Also oxidizes L-histidinal. -!- The Neurospora enzyme also catalyzes the reactions of EC 3.5.4.19 and EC 3.6.1.31.

UniProtKB Entries (1)

P06988
HISX_ECOLI
Escherichia coli K-12
Histidinol dehydrogenase

PDB Structure

PDB 1K75
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase.
Barbosa, J.A.R.G., Sivaraman, J., Li, Y., Larocque, R., Matte, A., Schrag, J.D., Cygler, M.
Proc.Natl.Acad.Sci.USA