CATH Domain 1jxiA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1190	UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
	3.40.1190.20	Ribokinase

Domain Context

CATH Clusters

Superfamily	3.40.1190.20
Functional Family	Phosphomethylpyrimidine kinase ThiD

Enzyme Information

2.7.4.7	Phosphooxymethylpyrimidine kinase. based on mapping to UniProt P55882 ATP + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine = ADP + 4-amino-2- methyl-5-(diphosphooxymethyl)pyrimidine.
2.7.1.49	Hydroxymethylpyrimidine kinase. based on mapping to UniProt P55882 ATP + 4-amino-5-hydroxymethyl-2-methylpyrimidine = ADP + 4-amino-2- methyl-5-(phosphomethyl)pyrimidine. -!- CTP, UTP and GTP can act as donors.

UniProtKB Entries (1)

THID_SALTY

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

PDB Structure

PDB	1JXI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution. Cheng, G., Bennett, E.M., Begley, T.P., Ealick, S.E. Structure