CATH Classification

Domain Context

CATH Clusters

Superfamily dopa decarboxylase, N-terminal domain
Functional Family Histidine decarboxylase

Enzyme Information

4.1.1.28
Aromatic-L-amino-acid decarboxylase.
based on mapping to UniProt P80041
(1) L-dopa = dopamine + CO(2). (2) 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO(2).
-!- Also acts on other aromatic L-amino acids, including L-tryptophan. -!- Formerly EC 4.1.1.26 and EC 4.1.1.27.

UniProtKB Entries (1)

P80041
DDC_PIG
Sus scrofa
Aromatic-L-amino-acid decarboxylase

PDB Structure

PDB 1JS6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase.
Burkhard, P., Dominici, P., Borri-Voltattorni, C., Jansonius, J.N., Malashkevich, V.N.
Nat.Struct.Biol.