CATH Domain 1jp7C00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1580	Nucleoside phosphorylase domain

Domain Context

CATH Clusters

Superfamily	Nucleoside phosphorylase domain
Functional Family

Enzyme Information

2.4.2.1	Purine-nucleoside phosphorylase. based on mapping to UniProt P50389 (1) Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. (2) Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate. -!- Specificity not completely determined. -!- Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5.
2.4.2.28	S-methyl-5'-thioadenosine phosphorylase. based on mapping to UniProt P50389 S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha- D-ribose 1-phosphate. -!- Also acts on 5'-deoxyadenosine and other analogs having 5'-deoxy groups.

UniProtKB Entries (1)

PNPH_SACS2

Saccharolobus solfataricus P2

Purine nucleoside phosphorylase

PDB Structure

PDB	1JP7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Three-dimensional structure of a hyperthermophilic 5'-deoxy-5'-methylthioadenosine phosphorylase from Sulfolobus solfataricus. Appleby, T.C., Mathews, I.I., Porcelli, M., Cacciapuoti, G., Ealick, S.E. J.Biol.Chem.