CATH Classification

Domain Context

CATH Clusters

Superfamily Thrombin light chain domain
Functional Family

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (1)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin

PDB Structure

PDB 1JMO
External Links
Method X-RAY DIFFRACTION
Organism Cricetulus
Primary Citation
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.
Baglin, T.P., Carrell, R.W., Church, F.C., Esmon, C.T., Huntington, J.A.
Proc.Natl.Acad.Sci.USA