CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Estrogen sulfotransferase

Enzyme Information
Bile-salt sulfotransferase.
based on mapping to UniProt Q06520
(1) 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate. (2) 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.
-!- The formation of sulfate esters of bile acids is an essential step in the prevention of toxicity by monohydroxy bile acids in many species. -!- This enzyme is both a bile salt and a 3-hydroxysteroid sulfotransferase. -!- In addition to the 5-beta-bile acid glycolithocholate, deoxycholate, 3-beta-hydroxy-5-cholenoate and dehydroepiandrosterone (3-beta- hydroxyandrost-5-en-17-one) also act as substrates (see also EC and EC -!- May be identical to EC

UniProtKB Entries (1)

Homo sapiens
Bile salt sulfotransferase

PDB Structure

PDB 1J99
External Links
Organism Escherichia
Primary Citation
Crystal structure of human dehydroepiandrosterone sulphotransferase in complex with substrate.
Rehse, P.H., Zhou, M., Lin, S.X.