CATH Classification

Domain Context

CATH Clusters

Superfamily Ricin (A Subunit), domain 2
Functional Family

Enzyme Information

3.2.2.22
rRNA N-glycosylase.
based on mapping to UniProt P09989
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.

UniProtKB Entries (1)

P09989
RIPT_TRIKI
Trichosanthes kirilowii
Ribosome-inactivating protein alpha-trichosanthin

PDB Structure

PDB 1J4G
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
crystal structure analysis of the trichosanthin delta C7
Ding, Y., Too, H.M., Wang, Z.L., Liu, Y.W., Dong, Y.C., Shaw, P.C., Rao, Z.H.
To be Published