CATH Domain 1j3kA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.430	Dihydrofolate Reductase, subunit A
	3.40.430.10	Dihydrofolate Reductase, subunit A

Domain Context

CATH Clusters

Superfamily	Dihydrofolate Reductase, subunit A
Functional Family	Bifunctional dihydrofolate reductase-thymidylate synthase

Enzyme Information

2.1.1.45	Thymidylate synthase. based on mapping to UniProt P13922 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
1.5.1.3	Dihydrofolate reductase. based on mapping to UniProt P13922 5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH. -!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

DRTS_PLAFK

Plasmodium falciparum K1

Bifunctional dihydrofolate reductase-thymidylate synthase

PDB Structure

PDB	1J3K
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Insights into antifolate resistance from malarial DHFR-TS structures. Yuvaniyama, J., Chitnumsub, P., Kamchonwongpaisan, S., Vanichtanankul, J., Sirawaraporn, W., Taylor, P., Walkinshaw, M.D., Yuthavong, Y. NAT.STRUCT.BIOL.