CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Endothiapepsin

Enzyme Information

3.4.23.18
Aspergillopepsin I.
based on mapping to UniProt P0CU33
Hydrolysis of proteins with broad specificity. Generally favors hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen. Does not clot milk.
-!- Found in a variety of Aspergillus species (imperfect fungi): A.awamori, A.foetidus, A.fumigatus, A.kawachii, A.niger, A.oryzae, A.saitoi, and A.sojae. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.23.6.

UniProtKB Entries (1)

P0CU33
PEPA_ASPOZ
Aspergillus oryzae
Aspergillopepsin-1

PDB Structure

PDB 1IZD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of Aspergillus oryzae Aspartic Proteinase and its Complex with an Inhibitor Pepstatin at 1.9 A Resolution
Kamitori, S., Ohtaki, A., Ino, H., Takeuchi, M.
J.Mol.Biol.