CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

Enzyme Information

3.2.2.6
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
based on mapping to UniProt Q10588
NAD(+) + H(2)O = ADP-D-ribose + nicotinamide.
-!- This multiunctional enzyme catalyzes both the synthesis and hydrolysis of cyclic ADP-ribose, a calcium messenger that can mobilize intracellular Ca(2+) stores and activate Ca(2+) influx to regulate a wide range of physiological processes. -!- In addition, the enzyme also catalyzes EC 2.4.99.20. -!- It is also able to act on beta-nicotinamide D-ribonucleotide. -!- Cf. EC 3.2.2.5.

UniProtKB Entries (1)

Q10588
BST1_HUMAN
Homo sapiens
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2

PDB Structure

PDB 1ISM
External Links
Method X-RAY DIFFRACTION
Organism Trichoplusia
Primary Citation
Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities.
Yamamoto-Katayama, S., Ariyoshi, M., Ishihara, K., Hirano, T., Jingami, H., Morikawa, K.
J.Mol.Biol.