CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family 7,8-dihydro-8-oxoguanine triphosphatase

Enzyme Information
2-hydroxy-dATP diphosphatase.
based on mapping to UniProt P36639
2-hydroxy-dATP + H(2)O = 2-hydroxy-dAMP + diphosphate.
-!- The enzyme hydrolyzes oxidized purine nucleoside triphosphates such as 2-hydroxy-dATP, thereby preventing their misincorporation into DNA. -!- It can also recognize 8-oxo-dGTP and 8-oxo-dATP, but with lower efficiency (cf. EC
8-oxo-dGTP diphosphatase.
based on mapping to UniProt P36639
8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.
-!- This enzyme hydrolyzes the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. -!- It does not hydrolyze 2-hydroxy-dATP (cf. EC

UniProtKB Entries (1)

Homo sapiens
7,8-dihydro-8-oxoguanine triphosphatase

PDB Structure

External Links
Organism Escherichia
Primary Citation
Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates
Mishima, M., Sakai, Y., Itoh, N., Kamiya, H., Furuichi, M., Takahashi, M., Yamagata, Y., Iwai, S., Nakabeppu, Y., Shirakawa, M.