CATH Classification

Domain Context

CATH Clusters

Superfamily Herpesvirus/Caudovirus protease domain
Functional Family Capsid scaffolding protein

Enzyme Information

3.4.21.97
Assemblin.
based on mapping to UniProt P16753
Cleaves -Ala-|-Ser- and -Ala-|-Ala- bonds in the scaffold protein.
-!- Involved in the breakdown of the scaffold protein during the late stages of assembly of the herpes-virus virion. -!- Inhibited by diisopropyl fluorophosphate. -!- Belongs to peptidase family S21.

UniProtKB Entries (1)

P16753
SCAF_HCMVA
Human herpesvirus 5 strain AD169
Capsid scaffolding protein

PDB Structure

PDB 1IEC
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Investigating the role of histidine 157 in the catalytic activity of human cytomegalovirus protease.
Khayat, R., Batra, R., Massariol, M.J., Lagace, L., Tong, L.
Biochemistry