CATH Domain 1hwwA03
|126.96.36.1990||Golgi alpha-mannosidase II|
|Superfamily||Golgi alpha-mannosidase II|
|Functional Family||Alpha-mannosidase 2|
based on mapping to UniProt Q24451
Man(5)GlcNAc(3)-[protein] + 2 H(2)O = Man(3)GlcNAc(3)-[protein] + 2 alpha-D-mannopyranose.
-!- The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. -!- It removes two mannosyl residues, one linked by alpha-1,3 linkage, and the other linked by alpha-1,6 linkage, both of which are removed by the same catalytic site. -!- The enzyme is sensitive to swainsonine.
UniProtKB Entries (1)
Structure of Golgi alpha-mannosidase II: a target for inhibition of growth and metastasis of cancer cells.