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1 keywords

CATH Domain 1hrtI00

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.70 Distorted Sandwich
Topology 2.70.10 Thrombin Inhibitor (Hirudin); Chain I
Homologous Superfamily 2.70.10.10 Thrombin Inhibitor (Hirudin), subunit I

Domain Context

CATH Clusters

Superfamily Thrombin Inhibitor (Hirudin), subunit I
Functional Family Hirudin variant-1

Enzyme Information

UniProtKB Entries (2)

P01050
HIRV1_HIRME
Hirudo medicinalis
Hirudin variant-1
P00735
THRB_BOVIN
Bos taurus
Prothrombin

PDB Structure

PDB 1HRT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structure of a complex of bovine alpha-thrombin and recombinant hirudin at 2.8-A resolution.
Vitali, J., Martin, P.D., Malkowski, M.G., Robertson, W.D., Lazar, J.B., Winant, R.C., Johnson, P.H., Edwards, B.F.
J.Biol.Chem.
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