CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family 3,2-trans-enoyl-CoA isomerase

Enzyme Information
Delta(3)-Delta(2)-enoyl-CoA isomerase.
based on mapping to UniProt Q05871
(1) A (3Z)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA. (2) A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.
-!- The enzyme participates in the beta-oxidation of fatty acids with double bonds at an odd position. -!- Processing of these substrates via the beta-oxidation system results in intermediates with a cis- or trans-double bond at position C(3), which cannot be processed further by the regular enzymes of the beta- oxidation system. -!- This enzyme isomerizes the bond to a trans bond at position C(2), which can be processed further. -!- The reaction rate is ten times higher for the (3Z) isomers than for (3E) isomers. -!- The enzyme can also catalyze the isomerization of 3-acetylenic fatty acyl thioesters to 2,3-dienoyl fatty acyl thioesters.

UniProtKB Entries (1)

Saccharomyces cerevisiae S288C
3,2-trans-enoyl-CoA isomerase

PDB Structure

External Links
Organism Escherichia
Primary Citation
The crystal structure of delta(3)-delta(2)-enoyl-CoA isomerase.
Mursula, A.M., van Aalten, D.M., Hiltunen, J.K., Wierenga, R.K.