CATH Domain 1hbuD01
|3.90.390||Methyl-coenzyme M Reductase; Chain A, domain 1|
|3.90.390.10||Methyl-coenzyme M Reductase; Chain A, domain 1|
|Superfamily||Methyl-coenzyme M Reductase; Chain A, domain 1|
based on mapping to UniProt P11558
Methyl-CoM + CoB = CoM-S-S-CoB + methane.
-!- This enzyme catalyzes the final step in methanogenesis, the biological production of methane. -!- This important anaerobic process is carried out only by methanogenic archaea. -!- The enzyme can also function in reverse, for anaerobic oxidation of methane. -!- The enzyme requires the hydroporphinoid nickel complex coenzyme F(430). -!- Highly specific for coenzyme B with a heptanoyl chain; ethyl CoM and difluoromethyl CoM are poor substrates. -!- The sulfide sulfur can be replaced by selenium but not by oxygen.
UniProtKB Entries (1)
Methanothermobacter marburgensis str. Marburg
Methyl-coenzyme M reductase I subunit alpha
On the Mechanism of Biological Methane Formation: Structural Evidence for Conformational Changes in Methyl-Coenzyme M Reductase Upon Substrate Binding