CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.1330.30
Functional Family 23S rRNA methyltransferase

Enzyme Information

2.1.1.185
23S rRNA (guanosine(2251)-2'-O)-methyltransferase.
based on mapping to UniProt P63177
S-adenosyl-L-methionine + guanosine(2251) in 23S rRNA = S-adenosyl-L- homocysteine + 2'-O-methylguanosine(2251) in 23S rRNA.
-!- The enzyme catalyzes the methylation of guanosine(2251), a modification conserved in the peptidyltransferase domain of 23S rRNA.

UniProtKB Entries (1)

P63177
RLMB_ECOLI
Escherichia coli K-12
23S rRNA (guanosine-2'-O-)-methyltransferase RlmB

PDB Structure

PDB 1GZ0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Structure of the Rlmb 23S Rrna Methyltransferase Reveals a New Methyltransferase Fold with a Unique Knot
Michel, G., Sauve, V., Larocque, R., Li, Y., Matte, A., Cygler, M.
Structure