CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.20
Functional Family Dihydropyrimidine dehydrogenase [NADP(+)]

Enzyme Information

1.3.1.2
Dihydropyrimidine dehydrogenase (NADP(+)).
based on mapping to UniProt Q28943
5,6-dihydrouracil + NADP(+) = uracil + NADPH.
-!- Also acts on dihydrothymine.

UniProtKB Entries (1)

Q28943
DPYD_PIG
Sus scrofa
Dihydropyrimidine dehydrogenase [NADP(+)]

PDB Structure

PDB 1GTE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer.
Dobritzsch, D., Ricagno, S., Schneider, G., Schnackerz, K.D., Lindqvist, Y.
J. Biol. Chem.