CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.390.30
Functional Family Glutathione reductase

Enzyme Information

1.8.1.7
Glutathione-disulfide reductase.
based on mapping to UniProt P00390
2 glutathione + NADP(+) = glutathione disulfide + NADPH.
-!- Activity is dependent on a redox-active disulfide in each of the active centers. -!- Formerly EC 1.6.4.2.

UniProtKB Entries (1)

P00390
GSHR_HUMAN
Homo sapiens
Glutathione reductase, mitochondrial

PDB Structure

PDB 1GRH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibition of human glutathione reductase by the nitrosourea drugs 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea. A crystallographic analysis.
Karplus, P.A., Krauth-Siegel, R.L., Schirmer, R.H., Schulz, G.E.
Eur.J.Biochem.