CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family

Enzyme Information
DNA helicase.
based on mapping to UniProt O29238
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC (RNA helicase).
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt O29238
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC -!- Formerly EC

UniProtKB Entries (1)

Archaeoglobus fulgidus DSM 4304
Reverse gyrase

PDB Structure

External Links
Primary Citation
Crystal Structure of Reverse Gyrase: Insights Into the Positive Supercoiling of DNA.
Rodriguez, A.C., Stock, D.
Embo J.