CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.1190 | UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase |
|
3.40.1190.10 | Mur-like, catalytic domain |
Domain Context
CATH Clusters
| Superfamily | Mur-like, catalytic domain |
| Functional Family | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase |
Enzyme Information
| 6.3.2.10 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase.
based on mapping to UniProt P11880
ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl- D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D- glutamyl-L-lysyl-D-alanyl-D-alanine.
-!- Involved with EC 6.3.2.4, EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8 and EC 6.3.2.9 in the synthesis of a cell-wall peptide. -!- Also catalyzes the reaction when the C-terminal residue of the tripeptide is meso-2,4-diaminoheptanedioate (acylated at its L-center), linking the D-Ala--D-Ala to the carboxy group of the L-center. -!- Formerly EC 6.3.2.15.
|
UniProtKB Entries (1)
| P11880 |
MURF_ECOLI
Escherichia coli K-12
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
|
PDB Structure
| PDB | 1GG4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of Escherichia coli UDPMurNAc-tripeptide d-alanyl-d-alanine-adding enzyme (MurF) at 2.3 A resolution.
J.Mol.Biol.
|
