CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family Glutathione reductase

Enzyme Information

1.8.1.7
Glutathione-disulfide reductase.
based on mapping to UniProt P06715
2 glutathione + NADP(+) = glutathione disulfide + NADPH.
-!- Activity is dependent on a redox-active disulfide in each of the active centers. -!- Formerly EC 1.6.4.2.

UniProtKB Entries (1)

P06715
GSHR_ECOLI
Escherichia coli K-12
Glutathione reductase

PDB Structure

PDB 1GER
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of glutathione reductase from Escherichia coli at 1.86 A resolution: comparison with the enzyme from human erythrocytes.
Mittl, P.R., Schulz, G.E.
Protein Sci.