CATH Classification

Domain Context

CATH Clusters

Superfamily Isopropylmalate Dehydrogenase
Functional Family 3-isopropylmalate dehydrogenase

Enzyme Information

1.1.1.85
3-isopropylmalate dehydrogenase.
based on mapping to UniProt Q5SIY4
(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO(2) + NADH.

UniProtKB Entries (1)

Q5SIY4
LEU3_THET8
Thermus thermophilus HB8
3-isopropylmalate dehydrogenase

PDB Structure

PDB 1GC9
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Design, X-ray crystallography, molecular modelling and thermal stability studies of mutant enzymes at site 172 of 3-isopropylmalate dehydrogenase from Thermus thermophilus.
Qu, C., Akanuma, S., Tanaka, N., Moriyama, H., Oshima, T.
Acta Crystallogr.,Sect.D