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CATH Domain 1g2wA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.470 D-amino Acid Aminotransferase; Chain A, domain 1
Homologous Superfamily 3.30.470.10 Aminotransferase class 4, branched-chain amino acid transferase, N-terminal domain

Domain Context

CATH Clusters

Superfamily 3.30.470.10
Functional Family D-alanine aminotransferase

Enzyme Information

2.6.1.21
D-amino-acid transaminase.
based on mapping to UniProt P19938
D-alanine + 2-oxoglutarate = pyruvate + D-glutamate.
-!- The enzyme from thermophilic Bacillus species acts on many D-amino acids with D-alanine and D-2-aminobutyrate as the best amino donors. -!- It can similarly use any of several 2-oxo acids as amino acceptor, with 2-oxoglutarate and 2-oxobutyrate among the best. -!- The enzyme from some other sources has a broader specificity. -!- Formerly EC 2.6.1.10.

UniProtKB Entries (1)

P19938
DAAA_BACYM
Bacillus sp. YM-1
D-alanine aminotransferase

PDB Structure

PDB 1G2W
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Studies on an Active Site Residue, E177, That Affects Binding of the Coenzyme in D-Amino Acid Transaminase, and Mechanistic Studies on a Suicide Substrate
van Ophem, P.W., Lepore, B.W., Kishimoto, K., Ringe, D., Manning, J.M.
Biochemistry and Molecular Biology of Vitamin B6 and PQQ-dependent Proteins, 10th Annual International Symposium on Vitamin B6
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