CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Vacuolar aspartic proteinase

Enzyme Information

3.4.23.25
Saccharopepsin.
based on mapping to UniProt P07267
Hydrolysis of proteins with broad specificity for peptide bonds. Cleaves -Leu-Leu-|-Val-Tyr- bond in a synthetic substrate. Does not act on esters of Tyr or Arg.
-!- Located in the vacuole. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.17, EC 3.4.23.6 and EC 3.4.23.8.

UniProtKB Entries (1)

P07267
CARP_YEAST
Saccharomyces cerevisiae S288C
Saccharopepsin

PDB Structure

PDB 1G0V
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiae.
Phylip, L.H., Lees, W.E., Brownsey, B.G., Bur, D., Dunn, B.M., Winther, J.R., Gustchina, A., Li, M., Copeland, T., Wlodawer, A., Kay, J.
J.Biol.Chem.