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1 keywords

CATH Domain 1fv3A01

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.60 Sandwich
Topology 2.60.120 Jelly Rolls
Homologous Superfamily 2.60.120.200  

Domain Context

CATH Clusters

Superfamily 2.60.120.200
Functional Family Tetanus toxin

Enzyme Information

3.4.24.68
Tentoxilysin.
based on mapping to UniProt P04958
Hydrolysis of 76-Gln-|-Phe-77 bond in synaptobrevin 2.
-!- Belongs to peptidase family M27.

UniProtKB Entries (1)

P04958
TETX_CLOTE
Clostridium tetani E88
Tetanus toxin

PDB Structure

PDB 1FV3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of tetanus toxin Hc fragment complexed with a synthetic GT1b analogue suggests cross-linking between ganglioside receptors and the toxin.
Fotinou, C., Emsley, P., Black, I., Ando, H., Ishida, H., Kiso, M., Sinha, K.A., Fairweather, N.F., Isaacs, N.W.
J.Biol.Chem.
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