CATH Classification

Domain Context

CATH Clusters

Superfamily Glutamine synthetase, N-terminal domain
Functional Family Glutamine synthetase

Enzyme Information

6.3.1.2
Glutamine synthetase.
based on mapping to UniProt P0A1P6
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.
-!- Glutamine synthetase, which catalyzes the incorporation of ammonium into glutamate, is a key enzyme of nitrogen metabolism found in all domains of life. -!- Several types have been described, differing in their oligomeric structures and cofactor requirements.

UniProtKB Entries (1)

P0A1P6
GLN1B_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Glutamine synthetase

PDB Structure

PDB 1FPY
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition.
Gill, H.S., Eisenberg, D.
Biochemistry