CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family Formate--tetrahydrofolate ligase

Enzyme Information

6.3.4.3
Formate--tetrahydrofolate ligase.
based on mapping to UniProt P21164
ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.
-!- In eukaryotes occurs as a trifunctional enzyme also having EC 1.5.1.5 and EC 3.5.4.9 activity.

UniProtKB Entries (1)

P21164
FTHS_MOOTH
Moorella thermoacetica
Formate--tetrahydrofolate ligase

PDB Structure

PDB 1FPM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Cation binding and thermostability of FTHFS monovalent cation binding sites and thermostability of N10-formyltetrahydrofolate synthetase from Moorella thermoacetica.
Radfar, R., Leaphart, A., Brewer, J.M., Minor, W., Odom, J.D., Dunlap, R.B., Lovell, C.R., Lebioda, L.
Biochemistry