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1 keywords

CATH Domain 1fggA00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.90 Alpha-Beta Complex
Topology 3.90.550 Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Homologous Superfamily 3.90.550.10 Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A

Domain Context

CATH Clusters

Superfamily Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase

Enzyme Information

2.4.1.135
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase.
based on mapping to UniProt O94766
UDP-alpha-D-glucuronate + [protein]-3-O-(beta-D-galactosyl-(1->3)-beta-D- galactosyl-(1->4)-beta-D-xylosyl)-L-serine = UDP + [protein]-3-O-(beta-D- GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine.
-!- Involved in the biosynthesis of the linkage region of glycosaminoglycan chains as part of proteoglycan biosynthesis (chondroitin, dermatan and heparan sulfates).

UniProtKB Entries (1)

O94766
B3GA3_HUMAN
Homo sapiens
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

PDB Structure

PDB 1FGG
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I.
Pedersen, L.C., Tsuchida, K., Kitagawa, H., Sugahara, K., Darden, T.A., Negishi, M.
J.Biol.Chem.
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