CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information
Proton-translocating NAD(P)(+) transhydrogenase.
based on mapping to UniProt Q2RSB2
NADPH + NAD(+) + H(+)(Side 1) = NADP(+) + H(+)(Side 2) + NADH.
-!- The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane. -!- In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH. -!- Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme. -!- Formerly EC

UniProtKB Entries (1)

Rhodospirillum rubrum ATCC 11170
NAD(P) transhydrogenase subunit alpha part 1

PDB Structure

External Links
Organism Escherichia
Primary Citation
Protein-protein recognition, hydride transfer and proton pumping in the transhydrogenase complex.
Buckley, P.A., Baz Jackson, J., Schneider, T., White, S.A., Rice, D.W., Baker, P.J.
Structure Fold.Des.