CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.590 | Creatine Kinase; Chain A, domain 2 |
|
3.30.590.10 | Glutamine synthetase/guanido kinase, catalytic domain |
Domain Context
CATH Clusters
| Superfamily | Glutamine synthetase/guanido kinase, catalytic domain |
| Functional Family | Glutamine synthetase |
Enzyme Information
| 6.3.1.2 |
Glutamine synthetase.
based on mapping to UniProt P0A1P6
ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.
-!- Glutamine synthetase, which catalyzes the incorporation of ammonium into glutamate, is a key enzyme of nitrogen metabolism found in all domains of life. -!- Several types have been described, differing in their oligomeric structures and cofactor requirements.
|
UniProtKB Entries (1)
| P0A1P6 |
GLN1B_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Glutamine synthetase
|
PDB Structure
| PDB | 1F52 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition.
Biochemistry
|
