CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoenolpyruvate-binding domains
Functional Family Pyruvate kinase

Enzyme Information

2.7.1.40
Pyruvate kinase.
based on mapping to UniProt P11974
ATP + pyruvate = ADP + phosphoenolpyruvate.
-!- UTP, GTP, CTP, ITP and dATP can also act as donors. -!- Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).

UniProtKB Entries (1)

P11974
KPYM_RABIT
Oryctolagus cuniculus
Pyruvate kinase PKM

PDB Structure

PDB 1F3W
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and functional linkages between subunit interfaces in mammalian pyruvate kinase.
Wooll, J.O., Friesen, R.H., White, M.A., Watowich, S.J., Fox, R.O., Lee, J.C., Czerwinski, E.W.
J.Mol.Biol.