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1 keywords

CATH Domain 1f34A02

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.40 Beta Barrel
Topology 2.40.70 Cathepsin D, subunit A; domain 1
Homologous Superfamily 2.40.70.10 Acid Proteases

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family

Enzyme Information

3.4.23.1
Pepsin A.
based on mapping to UniProt P00791
Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves 1-Phe-|-Val-2, 4-Gln-|-His-5, 13-Glu-|-Ala-14, 14-Ala-|-Leu-15, 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17, 23-Gly-|-Phe-24, 24-Phe-|-Phe-25 and 25-Phe-|-Tyr-26 bonds in the B chain of insulin.
-!- The predominant endopeptidase in the gastric juice of vertebrates, formed from pepsinogen A by limited proteolysis. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.1.

UniProtKB Entries (2)

P19400
API3_ASCSU
Ascaris suum
Major pepsin inhibitor 3
P00791
PEPA_PIG
Sus scrofa
Pepsin A

PDB Structure

PDB 1F34
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3.
Ng, K.K., Petersen, J.F., Cherney, M.M., Garen, C., Zalatoris, J.J., Rao-Naik, C., Dunn, B.M., Martzen, M.R., Peanasky, R.J., James, M.N.
Nat.Struct.Biol.
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