CATH Domain 1f28D00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.572	Thymidylate Synthase; Chain A
	3.30.572.10	Thymidylate synthase/dCMP hydroxymethylase domain

Domain Context

CATH Clusters

Superfamily	Thymidylate synthase/dCMP hydroxymethylase domain
Functional Family

Enzyme Information

2.1.1.45

Thymidylate synthase.

based on mapping to UniProt P13100

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

UniProtKB Entries (1)

TYSY_PNECA

Pneumocystis carinii

Thymidylate synthase

PDB Structure

PDB	1F28
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Approaches to solving the rigid receptor problem by identifying a minimal set of flexible residues during ligand docking. Anderson, A.C., O'Neil, R.H., Surti, T.S., Stroud, R.M. Chem.Biol.