CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P00523
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00523
SRC_CHICK
Gallus gallus
Proto-oncogene tyrosine-protein kinase Src

PDB Structure

PDB 1F1W
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for specificity switching of the Src SH2 domain.
Kimber, M.S., Nachman, J., Cunningham, A.M., Gish, G.D., Pawson, T., Pai, E.F.
Mol.Cell