CATH Classification

Domain Context

CATH Clusters

Superfamily Alkaline Phosphatase, subunit A
Functional Family Alkaline phosphatase

Enzyme Information

3.1.3.1
Alkaline phosphatase.
based on mapping to UniProt P05187
A phosphate monoester + H(2)O = an alcohol + phosphate.
-!- Active at a high pH optimum. -!- Wide specificity. -!- Also catalyzes transphosphorylations. -!- Some enzymes hydrolyze diphosphate (cf. EC 3.6.1.1).

UniProtKB Entries (1)

P05187
PPB1_HUMAN
Homo sapiens
Alkaline phosphatase, placental type

PDB Structure

PDB 1EW2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.
Le Du, M.H., Stigbrand, T., Taussig, M.J., Menez, A., Stura, E.A.
J.Biol.Chem.