CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Homoserine dehydrogenase |
Enzyme Information
| 1.1.1.3 |
Homoserine dehydrogenase.
based on mapping to UniProt P31116
L-homoserine + NAD(P)(+) = L-aspartate 4-semialdehyde + NAD(P)H.
-!- The enzyme from Saccharomyces cerevisiae acts most rapidly with NAD(+); the Neurospora enzyme with NADP(+). -!- The enzyme from Escherichia coli is a multifunctional protein, which also catalyzes the reaction of EC 2.7.2.4.
|
UniProtKB Entries (1)
| P31116 |
DHOM_YEAST
Saccharomyces cerevisiae S288C
Homoserine dehydrogenase
|
PDB Structure
| PDB | 1EBF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases.
Nat.Struct.Biol.
|
