CATH Domain 1e2tE01

CATH Classification

Level	CATH Code	Description
	6	Special
	6.10	Helix non-globular
	6.10.140	Helix Hairpins
	6.10.140.1930

Domain Context

CATH Clusters

Superfamily	6.10.140.1930
Functional Family

Enzyme Information

2.3.1.118	N-hydroxyarylamine O-acetyltransferase. based on mapping to UniProt Q00267 Acetyl-CoA + an N-hydroxyarylamine = CoA + an N-acetoxyarylamine. -!- The enzyme from liver, but not that from bacteria, can also catalyze N-acetylation of arylamines and N,O-acetylation of arylhydroxamates.
2.3.1.5	Arylamine N-acetyltransferase. based on mapping to UniProt Q00267 Acetyl-CoA + an arylamine = CoA + an N-acetylarylamine. -!- Wide specificity for aromatic amines, including serotonin; also catalyzes acetyl-transfer between arylamines without CoA.

UniProtKB Entries (1)

NHOA_SALTY

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Arylamine N-acetyltransferase / N-hydroxyarylamine O-acetyltransferase

PDB Structure

PDB	1E2T
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of Arylamine N-Acetyltransferase Reveals a Catalytic Triad Sinclair, J.C., Sandy, J., Delgoda, R., Sim, E., Noble, M.E.M. Nat.Struct.Biol.