CATH Classification

Domain Context

CATH Clusters

Superfamily Heme oxygenase-like
Functional Family Heme oxygenase 1

Enzyme Information
Heme oxygenase (biliverdin-producing).
based on mapping to UniProt P06762
Protoheme + 3 [reduced NADPH--hemoprotein reductase] + 3 O(2) = biliverdin + Fe(2+) + CO + 3 [oxidized NADPH--hemoprotein reductase] + 3 H(2)O.
-!- This mammalian enzyme participates in the degradation of heme. -!- The terminal oxygen atoms that are incorporated into the carbonyl groups of pyrrole rings A and B of biliverdin are derived from two separate oxygen molecules. -!- The third oxygen molecule provides the oxygen atom that converts the alpha-carbon to CO. -!- The enzyme requires NAD(P)H and EC -!- Cf. EC -!- Formerly EC

UniProtKB Entries (1)

Rattus norvegicus
Heme oxygenase 1

PDB Structure

External Links
Organism Escherichia
Primary Citation
Crystal structure of rat heme oxygenase-1 in complex with heme.
Sugishima, M., Omata, Y., Kakuta, Y., Sakamoto, H., Noguchi, M., Fukuyama, K.
FEBS Lett.