CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Short-chain dehydrogenase reductase |
Enzyme Information
| 1.1.1.252 |
Tetrahydroxynaphthalene reductase.
based on mapping to UniProt Q12634
Scytalone + NADP(+) = 1,3,6,8-tetrahydroxynaphthalene + NADPH.
-!- Reduces 1,3,6,8-tetrahydroxynaphthalene to scytalone and also reduces 1,3,8-trihydroxynaphthalene to vermelone. -!- Involved with EC 4.2.1.94 in the biosynthesis of melanin in pathogenic fungi. -!- Formerly EC 1.3.1.50.
|
UniProtKB Entries (1)
| Q12634 |
T4HR_MAGO7
Pyricularia oryzae 70-15
Tetrahydroxynaphthalene reductase
|
PDB Structure
| PDB | 1DOH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structures of trihydroxynaphthalene reductase-fungicide complexes: implications for structure-based design and catalysis.
Structure
|
