CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.40
Functional Family Glutaminase-asparaginase

Enzyme Information

3.5.1.38
Glutamin-(asparagin-)ase.
based on mapping to UniProt P10182
(1) L-glutamine + H(2)O = L-glutamate + NH(3). (2) L-asparagine + H(2)O = L-aspartate + NH(3).
-!- L-asparagine is hydrolyzed at 0.8 of the rate of L-glutamine. -!- The D-isomers are also hydrolyzed, more slowly. -!- Cf. EC 3.5.1.1 and EC 3.5.1.2.

UniProtKB Entries (1)

P10182
ASPQ_PSES7
Pseudomonas sp. ATCC29598
Glutaminase-asparaginase

PDB Structure

PDB 1DJP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Reactions of Pseudomonas 7A glutaminase-asparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu.
Ortlund, E., Lacount, M.W., Lewinski, K., Lebioda, L.
Biochemistry