CATH Classification

Domain Context

CATH Clusters

Superfamily Pseudouridine synthase I, catalytic domain, N-terminal subdomain
Functional Family tRNA pseudouridine synthase A

Enzyme Information

5.4.99.12
tRNA pseudouridine(38-40) synthase.
based on mapping to UniProt P07649
tRNA uridine(38-40) = tRNA pseudouridine(38-40).
-!- The uridylate residues at positions 38, 39 and 40 of nearly all tRNAs are isomerized to pseudouridine. -!- TruA specifically modifies uridines at positions 38, 39, and/or 40 in the anticodon stem loop of tRNAs with highly divergent sequences and structures.

UniProtKB Entries (1)

P07649
TRUA_ECOLI
Escherichia coli K-12
TRNA pseudouridine synthase A

PDB Structure

PDB 1DJ0
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I.
Foster, P.G., Huang, L., Santi, D.V., Stroud, R.M.
Nat.Struct.Biol.