CATH Domain 1dibB02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.10860	Leucine Dehydrogenase, chain A, domain 1

Domain Context

CATH Clusters

Superfamily	Leucine Dehydrogenase, chain A, domain 1
Functional Family	C-1-tetrahydrofolate synthase, cytoplasmic, putative

Enzyme Information

6.3.4.3	Formate--tetrahydrofolate ligase. based on mapping to UniProt P11586 ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. -!- In eukaryotes occurs as a trifunctional enzyme also having EC 1.5.1.5 and EC 3.5.4.9 activity.
3.5.4.9	Methenyltetrahydrofolate cyclohydrolase. based on mapping to UniProt P11586 5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.
1.5.1.5	Methylenetetrahydrofolate dehydrogenase (NADP(+)). based on mapping to UniProt P11586 5,10-methylenetetrahydrofolate + NADP(+) = 5,10- methenyltetrahydrofolate + NADPH.

UniProtKB Entries (1)

C1TC_HUMAN

Homo sapiens

C-1-tetrahydrofolate synthase, cytoplasmic

PDB Structure

PDB	1DIB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Schmidt, A., Wu, H., MacKenzie, R.E., Chen, V.J., Bewly, J.R., Ray, J.E., Toth, J.E., Cygler, M. Biochemistry