CATH Domain 1d7jB00
|3.10.50||Chitinase A; domain 3|
|Functional Family||Peptidyl-prolyl cis-trans isomerase FKBP1A|
based on mapping to UniProt P62942
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.
UniProtKB Entries (1)
Peptidyl-prolyl cis-trans isomerase FKBP1A
X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies.