CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.47.10
Functional Family Chalcone synthase 1

Enzyme Information

2.3.1.74
Chalcone synthase.
based on mapping to UniProt P30074
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO(2).
-!- The enzyme catalyzes the first committed step in the biosynthesis of flavonoids. -!- It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.

UniProtKB Entries (1)

P30074
CHS2_MEDSA
Medicago sativa
Chalcone synthase 2

PDB Structure

PDB 1D6H
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase.
Jez, J.M., Ferrer, J.L., Bowman, M.E., Dixon, R.A., Noel, J.P.
Biochemistry