CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.10
Functional Family Endochitinase B1

Enzyme Information

3.2.1.14
Chitinase.
based on mapping to UniProt P0CB51
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

P0CB51
CHI1_COCPS
Coccidioides posadasii str. Silveira
Endochitinase 1

PDB Structure

PDB 1D2K
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The X-ray structure of a chitinase from the pathogenic fungus Coccidioides immitis.
Hollis, T., Monzingo, A.F., Bortone, K., Ernst, S., Cox, R., Robertus, J.D.
Protein Sci.