CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.367.20
Functional Family Hexokinase-1

Enzyme Information

2.7.1.1
Hexokinase.
based on mapping to UniProt P19367
ATP + D-hexose = ADP + D-hexose 6-phosphate.
-!- D-glucose, D-mannose, D-fructose, sorbitol and D-glucosamine can act as acceptors. -!- ITP and dATP can act as donors.

UniProtKB Entries (1)

P19367
HXK1_HUMAN
Homo sapiens
Hexokinase-1

PDB Structure

PDB 1CZA
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation.
Aleshin, A.E., Kirby, C., Liu, X., Bourenkov, G.P., Bartunik, H.D., Fromm, H.J., Honzatko, R.B.
J.Mol.Biol.